Table 6.
Enrichment of KEGG pathways using all genes found to be differentially expressed in response to E2 and/or Gen (analysis “All”). Significantly enriched pathways (FDR < 0.05) were identified by their KEGG identifier and have been grouped according to 7 functionally related groups obtained by ClueGO analysis. Each group is named after its most significant term (lowest FDR), which is indicated in bold. Functionally related groups are sorted by highest enrichment score, calculated as [- Log2 (group FDR)].
| KEGG Identifier | KEGG ID FDR | Group FDR | Enrichment Score | Groups | % Associated Genes | Nr. Genes |
|---|---|---|---|---|---|---|
| Steroid biosynthesis | 240.0E-9 | 210.0E-9 | 22.2 | 0 | 33.33 | 7.00 |
| ECM-receptor interaction | 1.5E-3 | 1.3E-3 | 9.6 | 5 | 8.64 | 7.00 |
| Alanine, aspartate and glutamate metabolism | 8.7E-3 | 3.0E-3 | 8.4 | 6 | 10.00 | 4.00 |
| Arginine biosynthesis | 10.0E-3 | 3.0E-3 | 8.4 | 6 | 12.00 | 3.00 |
| DNA replication | 9.6E-3 | 6.3E-3 | 7.3 | 2 | 10.53 | 4.00 |
| p53 signaling pathway | 12.0E-3 | 11.0E-3 | 6.5 | 4 | 6.76 | 5.00 |
| Arachidonic acid metabolism | 11.0E-3 | 12.0E-3 | 6.4 | 1 | 7.84 | 4.00 |
| Proteasome | 14.0E-3 | 14.0E-3 | 6.2 | 3 | 7.14 | 4.00 |