Table 8.
Enrichment of KEGG pathways by the genes differentially expressed in response to E2 or to Gen (Analyses “E2” vs “Gen”). Significantly enriched pathways (FDR < 0.05), identified by their KEGG identifier, are grouped according to 6 functionally related groups obtained by ClueGO analysis. Each group is named after its most significant term (lowest FDR) and is highlighted in bold. Functionally related groups are sorted by highest enrichment score, calculated as [- Log2 (group FDR)].
| KEGG Identifier | KEGG ID FDR | Group FDR | Enrichment Score | Groups | % Associated Genes | Nr. Genes | Treatment | %Genes Specific for E2 | %Genes Specific for Gen |
|---|---|---|---|---|---|---|---|---|---|
| Steroid biosynthesis | 210.0E-9 | 180.0E-9 | 22.4 | 0 | 33.33 | 7.00 | Specific for Gen | 0.00 | 100.00 |
| ECM-receptor interaction | 1.3E-3 | 1.1E-3 | 9.8 | 4 | 8.64 | 7.00 | Specific for E2 | 66.84 | 40.11 |
| Alanine, aspartate and glutamate metabolism | 7.6E-3 | 2.6E-3 | 8.6 | 5 | 10.00 | 4.00 | Specific for Gen | 21.53 | 86.14 |
| Arginine biosynthesis | 9.5E-3 | 2.6E-3 | 8.6 | 5 | 12.00 | 3.00 | Specific for Gen | 0.00 | 100.00 |
| DNA replication | 8.4E-3 | 5.4E-3 | 7.5 | 1 | 10.53 | 4.00 | Specific for Gen | 25.00 | 75.00 |
| p53 signaling pathway | 11.0E-3 | 9.5E-3 | 6.7 | 3 | 6.76 | 5.00 | Both treatments | 53.89 | 53.89 |
| Proteasome | 14.0E-3 | 14.0E-3 | 6.2 | 2 | 7.14 | 4.00 | Specific for E2 | 86.14 | 21.53 |