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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Surgery. 2019 Sep 13;166(6):1122–1127. doi: 10.1016/j.surg.2019.07.014

Table 3. Comparison of whole blood thrombin generation in healthy volunteers and trauma patients.

Numbers presented as median with 25 and 75 interquartile range.

Healthy Volunteers (n=10) Trauma patients (n=58) p value
Lag time (min) 7.0 (6.0-8.0) 3.8 (2.6-4.9) <0.001
Peak thrombin (nM) 82.5 (75.2-91.6) 125.5 (84.4-149.9) 0.003
Time to peak thrombin (min) 10.5 (9.7-12.2) 6.6 (4.9-9.2) <0.001
Maximum rate (nM/min) 21.3 (17.8-26.1) 42.6 (22.6-63.6) 0.006
ETP (nM.min) 728 (636-797) 823 (708-972) 0.02

ETP=endogenous thrombin potential