Table 2.
Cause-Specific Hazard Ratio of Ischemic Stroke by CRP Categories for Races Combined and Separately
| Hazard Ratios of Ischemic Stroke by C-reactive Protein Categories | |||||||
|---|---|---|---|---|---|---|---|
| Group | <1 mg/L | 1-3 mg/L | 3-10 mg/L | ≥10 mg/L | P for trend |
Interaction p Values for Race * lnCRP / Race * Categorical CRP |
|
| n Cases / N Non-Cases (%) | |||||||
| Adjustment Variables | All | 156 / 6,893 (2.3%) | 240 / 8,710 (2.8%) | 233 / 7,991 (2.9%) | 101 / 2,475 (4.1%) | ||
| Black | 51 / 2,131 (2.4%) | 94 / 3,207 (2.9%) | 99 / 3,651 (2.7%) | 52 / 1,396 (3.7%) | |||
| White | 105 / 4,762 (2.2%) | 146 / 5,503 (2.7%) | 134 / 4,340 (3.1%) | 49 / 1,079 (4.5%) | |||
| Demographic* | All | 1.0 (ref) | 1.23 (1.01–1.51) | 1.44 (1.17–1.78) | 2.32 (1.79–3.00) | <0.0001 | |
| Black | 1.0 | 1.23 (0.87–1.74) | 1.21 (0.85–1.71) | 1.99 (1.34–2.95) | 0.007 | 0.48 / 0.45 | |
| White | 1.0 | 1.22 (0.95–1.58) | 1.61 (1.24–2.08) | 2.57 (1.82–3.63) | <0.0001 | ||
| + Risk Factors† | All | 1.0 | 1.19 (0.96–1.46) | 1.26 (1.02–1.57) | 1.91 (1.46–2.50) | <0.0001 | |
| Black | 1.0 | 1.25 (0.87–1.79) | 1.10 (0.77–1.59) | 1.65 (1.08–2.51) | 0.07 | 0.40 / 0.32 | |
| White | 1.0 | 1.15 (0.88–1.49) | 1.38 (1.06–1.79) | 2.15 (1. 51–3.06) | <0.0001 | ||
| + Socioeconomic status‡ | All | 1.0 | 1.16 (0.94–1.43) | 1.23 (0.99–1.52) | 1.84 (1.40–2.41) | 0.0001 | |
| Black | 1.0 | 1.22 (0.85–1.75) | 1.08 (0.75–1.56) | 1.59 (1.04–2.42) | 0.09 | 0.48 / 0.39 | |
| White | 1.0 | 1.12 (0.87–1.46) | 1.33 (1.02–1.73) | 2.07 (1.46–2.95) | 0.0003 | ||
*
Adjusted for age, sex, race.
†
Additionally adjusted for hypertension status, systolic blood pressure, history of heart disease, diabetes, current smoking status, left ventricular hypertrophy and atrial fibrillation
‡
Additionally adjusted for income and education