Table 4.
Overview of resting-state network functional connectivity changes compared to controls and within patients in relation to language task performance over time.
| Network | +/- | Altered functional connectivity | T, p-FDR | |
|---|---|---|---|---|
| Pre (vs. controls) | ||||
| Language | ⇓ | Middle temporal gyrus L → superior temporal/inferior parietal L | −2.70, 0.046 | |
| Sensorimotor | ⇑ | Cerebellum 4/5/6 + vermis B → pre/post central gyrus L | 2.83, 0.032 | |
| vDMN | ⇓ | Middle frontal gyrus L → parahippocampal gyrus L | −2.99, 0.038 | |
| Visual | ⇑ | Thalamus L → middle/superior occipital gyrus R | 2.48, 0.048 | |
| Post (vs. controls) | ||||
| dDMN | ⇑ | Inferior parietal (angular) gyrus R → superior frontal gyrus R | 2.86, 0.037 | |
| ⇓ | Inferior parietal (angular) gyrus L ←→ middle cingulated gyrus | −2.88, 0.047 | ||
| Salience | ⇓ | Insula R → Insula L | −2.73, 0.043 | |
| Post Salience | ⇑ | Posterior insula L → superior parietal gyrus/precuneus R | 3.38, 0.015 | |
| Pre and Post (vs. controls) | ||||
| Visuospatial | ⇑ | Inferior parietal gyrus R → inferior parietal gyrus L | 3.16, 0.025 | |
| Improved task performance (within patients) | ||||
| vDMN | ⇑ | Posterior cingulate cortex ←→ middle/superior frontal gyrus R | 3.51, 0.013 | |
| dDMN | ⇓ | Anterior cingulate cortex / medial prefrontal gyrus L → hippocampus L | −3.51, 0.011 | |
| Visuospatial | ⇑ | Inferior temporal gyrus L → inferior parietal gyrus L | 3.13, 0.038 | |
| ⇑ | Inferior temporal gyrus L → cerebellum 7b/8 R | 2.82, 0.041 | ||
Pre = pre-surgery, post = post-surgery, ⇑ = increased and ⇓ = decreased functional resting-state connectivity compared to controls or within patients, R = right, L = left, B = bilateral. Corrected at FDR-seed level, two-sided, p<0.05.