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. 2019 Oct;7(20):540. doi: 10.21037/atm.2019.10.16

Figure 4.

Figure 4

Knockdown of HSPA2 activated Erk1/2 signaling transduction pathway. (A) Downregulation of HSPA2 related with Erk1/2 signaling transduction pathway and c-Myc protein. Western blot analysis of proteins in pathways involved in cell cycle regulation with A549 and H1975 cells transfected with HSPA2 siRNA and control cells. (B) Verification of the finding that HSPA2 knockdown triggers the activation of the Erk1/2 pathway. Cell cycle profiles of A549 and H1975 cells with or without HSPA2 knockdown or Selumetinib (1 µM) and error bars were determined by flow cytometry. *, P<0.05.