Table 5. Comparison of diagnostic abilities of studies used transit time to assess portal hypertension.
| Study | Patients | UCAs | Parameters | Reference standard | Cut-off | Correlation | Grade of PH | AUROC | Se/Sp/PPV/NPV/Ac/PLR/NLR | Ref. |
|---|---|---|---|---|---|---|---|---|---|---|
| Zhang et al. | 31 | SonoVue | HVHAT | FPP | NR | r=−0.90, P<0.001 | NR | NR | NR | (82) |
| PVHAT | FPP | NR | r=0.81, P<0.001 | NR | NR | NR | ||||
| Kim et al. | 71 | SonoVue | HVAT | HVPG | 14 s | r2=0.55, P<0.001 | CSPH | 0.973 | 93/87/91/90/NR/6.95/0.08 | (83) |
| Shimada et al. | 91 | Sonazoid | PET | HVPG | 13.5 s | r=0.46, P=0.001 | CSPH | 0.76 | 71/68/69/70/NR/NR/NR | (87) |
| PET | HVPG | 14.5 s | r=0.46, P=0.001 | SPH | 0.76 | 60/80/75/67/NR/NR/NR | ||||
| Jeong et al. | 53 | SonoVue | HVAT | HVPG | 19 s | r=−0.34 | SPH | 0.72 | 56/89/95/35/63/NR/NR | (84) |
| ITT | HVPG | 6 s | r=−0.61 | SPH | 0.94 | 91/89/97/73/91/NR/NR |
The four studies show the diagnostic abilities of transit time based on microbubble ultrasound contrast agents (UCAs). HVHAT, hepatic-vein-hepatic-artery interval time; PVHAT, portal-vein-hepatic-artery interval time; HVAT, hepatic vein arrival time; PET, peak enhancement time; ITT, intrahepatic transit time; FPP, free portal pressure; HVPG, hepatic venous pressure gradient; Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; Ac, accuracy; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CSPH, clinically significant portal hypertension; SPH, severe portal hypertension; AUROC, area under the receiver operating curve; NR, no report.