Table S3. Meta-regression analysis to detect the source of heterogeneity for the association between TIM-3 −574G/T SNP and the risk of cancer.

Genetic model	Variables	Coefficient	95% CI	P	t
T vs. G	Year	1.033	0.746–1.430	0.797	0.27
	Situation of control	2.190*	1.848–2.654*	0.043*	2.29
	Source of control	1.145	0.380–3.451	0.750	0.34
	Cancer type	0.912	0.360–2.310	0.796	−0.28
	Quality	0.900	0.458–1.767	0.687	−0.43
	Sample size	0.999	0.998–1.000	0.054	−2.70
GT vs. GG	Year	1.068	0.763–1.495	0.617	0.54
	Situation of control	2.488	0.950–6.513	0.058	2.63
	Source of control	1.138	0.355–3.646	0.774	0.31
	Cancer type	0.964	0.358–2.596	0.924	−0.10
	Quality	0.852	0.426–1.705	0.556	−0.64
	Sample size	0.999	0.998–1.000	0.057	−2.65
(TT+GT) vs. GG	Year	1.057	0.747–1.497	0.678	0.45
	Situation of control	2.471	0.944–6.470	0.059	2.61
	Source of control	1.155	0.346–3.852	0.757	0.33
	Cancer type	0.942	0.340–2.608	0.878	−0.16
	Quality	0.861	0.419–1.769	0.596	−0.58
	Sample size	0.999	0.998–1.000	0.052	−2.75

*, indicate statistically significant values (P<0.05). SNP, single nucleotide polymorphism; CI, confidence interval.