Table 3. Composition and action of Sijunzi Decoction.

Ingredients	Content	TCM action	Pharmacological action
Renshen (Radix Ginseng)	9 g	Tonifying qi, spleen and lung	(I) Regulating the balance of excitation and inhibition of central nervous system; (II) facilitation of memory acquisition, consolidation and reproduction; (III) stimulation of HPA axis; (IV) cardiotonic effect; (V) antioxidation and anti-inflammation effects
Baizhu (Rhizoma Atractylodis Macrocephalae)	9 g	Tonifying qi and strengthening spleen	(I) Improving immune function; (II) strengthening body; (III) regulating gastrointestinal motility; (IV) diuretic effect
Fulin (Poria)	9 g	Strengthening spleen and promoting diuresis	(I) Increasing the level of potassium in myocardium; (II) liver protective effect; (III) diuretic effect
Zhigancao (Radix Glycyrrhizae Preparata)	6 g	Tonifying qi and spleen, harmonizing herbal nature	(I) Regulating immune function; (II) promoting brain function; (III) anti-infection and anti-inflammation effects; (IV) antiarrhythmic effect

HPA, hypothalamic-pituitary-adrenal.