Table 2.
Lung cancer detection modality, stage and histology, cause of death, and corresponding all-cause and lung cancer-specific mortality rates (/100 000 person-years) in the pooled analysis (Italy, 2001–2011)
| Pooled analysis | |||
|---|---|---|---|
| LDCT arm (%) | Control arm (%) | All (%) | |
| Number of participants | 3640 | 2909 | 6549 |
| Person-years FU | 30 480 | 22 157 | 52 637 |
| Total patients with LC | 192 | 105 | 297 |
| Total deaths | 282 | 238 | 520 |
| Mode of detection | |||
| Screen detected | 136 (70.8) | 10 (9.5) | 146 (49.2) |
| Interval cancer | 56 (29.2) | 95 (90.5) | 151 (50.8) |
| Stage | |||
| IA | 68 (35.4) | 12 (11.4) | 80 (26.9) |
| IB | 23 (12.0) | 10 (9.5) | 33 (11.1) |
| II | 11 (5.7) | 7 (6.7) | 18 (6.1) |
| Othera | 90 (46.9) | 76 (72.4) | 166 (55.9) |
| Histotype | |||
| Adenocarcinoma | 95 (49.5) | 29 (27.6) | 124 (41.8) |
| Squamous cell carcinoma | 41 (21.4) | 22 (21.0) | 63 (21.2) |
| Othera | 56 (29.1) | 54 (51.4) | 110 (37.0) |
| Cause of death | |||
| Cancer of the lung | 91 (32.3) | 79 (33.2) | 170 (32.7) |
| Cancer of other organs | 95 (33.7) | 75 (31.5) | 170 (32.7) |
| Otherb | 96 (34.0) | 84 (35.3) | 180 (34.6) |
| All-cause mortality | |||
| Rate/100 000 person-years | 925 | 1074 | 988 |
| Lung cancer mortality | |||
| Rate/100 000 person-years | 299 | 357 | 323 |
FU, follow-up; LC, lung cancer; LDCT, low-dose computed tomography.
a
Including missing values (22 stage and 33 histotype).
b
One patient died of disseminated cancer of unknown origin, and one died of unknown causes in a foreign country.