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. 2019 Nov 14;25(42):6342–6353. doi: 10.3748/wjg.v25.i42.6342

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Examination of each ulcerogenic factor according to age. A: Helicobacter pylori (H. pylori) infections were more common in patients in their 30s to 70s. The rates decreased thereafter. However, the rates of H. pylori-positive and medicine-positive ulcers, and those of medicine-induced ulcers, increased significantly with age. Medicine-induced ulcers were most common in those in their 80s. There was no significant change over time in the incidence of H. pylori-induced and medicine-negative, so-called idiopathic, and ulcers. B and C: Rates of H. pylori infection and administration of non-steroidal anti-inflammatory drugs (NSAIDs), antiplatelets, and anticoagulants in 2006–2011, 2012–2016, and 2006–2016. Over time, the use of NSAIDs and antithrombotic drugs increased with age. By contrast, the rate of H. pylori infection during the study period fell with age.