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. 2019 Oct 25;18(6):4820–4828. doi: 10.3892/etm.2019.8136

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Dexmedetomidine enhances the hypoxia-induced invasion ability of cancer cells. (A) Representative images showing the invasion of the A549 cells. (B) Quantitative analysis of invasive cell number of A549 cells. (C) Representative images showing the invasion of the HCT116 cells. (D) Quantitative analysis of invasive cell number of HCT116 cells. The invasion ability of the two cells were detected by Matrigel assays. *P<0.05 vs. N; ^#P<0.05 vs. H; ⁺P<0.05 vs. HD; n=6 in each group; scale bars represent 50 µm. H, hypoxia; HD, hypoxia + dexmedetomidine; HAD, hypoxia + dexmedetomidine + atipamezole; N, normoxia.