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. 2019 Oct 25;18(6):4820–4828. doi: 10.3892/etm.2019.8136

Figure 5.

Figure 5.

Dexmedetomidine upregulates the mRNA levels of MMP-2 and MMP-9 in cancer cells in response to hypoxia treatment. (A) Quantitative analysis of MMP-2 and MMP-9 mRNA levels in the A549 cells. (B) Quantitative analysis of MMP-2 and MMP-9 mRNA levels in the HCT116 cells. The MMP-2 and MMP-9 mRNA expression levels of the two cells were evaluated by reverse transcription-quantitative PCR. *P<0.05 vs. N; #P<0.05 vs. H; +P<0.05 vs. HD; n=6 in each group; all values are normalized against the N group. H, hypoxia; HD, hypoxia + dexmedetomidine; HDA, hypoxia + dexmedetomidine + atipamezole; MMP, matrix metalloproteinase; N, normoxia.