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. 2019 Oct 29;20(21):5395. doi: 10.3390/ijms20215395

Figure 3.

Figure 3

Effect of test compounds on in vivo functional outcomes. Effects of vehicle (n = 15) and clomipramine (Clomi, n = 11) treatments on composite neuroscore, beam-walking, body weight and rectal temperature in rats with traumatic brain injury (TBI) were analysed using coefficient estimates of the linear mixed effects model. The treatment period (3–14 days) is indicated with a light green area in each panel. (A) Clomipramine administration impaired performance in the composite neuroscore test compared with vehicle treatment. (B) Performance in the beam-walking test was comparable between the Vehicle-TBI and Clomi-TBI groups. (C) Clomipramine delayed the post-TBI weight gain during the 3–14-days treatment period. After clomipramine discontinuation, rats stated to gain weight and by 21 days post-TBI, their weight did not differ from that in the vehicle group. (D) Rectal temperature was comparable in the Vehicle-TBI and Clomi-TBI groups throughout the entire study period. Statistical significance from: # p < 0.05 (significant main effects model); * p < 0.05 (significant estimates in model).