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. 2019 Oct 29;20(21):5395. doi: 10.3390/ijms20215395

Figure 4.

Figure 4

Effect of clomipramine on plasma cytokines and machine learning analysis. (A) A radar plot showing the levels of plasma cytokines in clomipramine (Clomi)-treated (orange, n = 11) and vehicle-treated (grey, n = 15) rats with lateral fluid-percussion-induced traumatic brain injury (TBI) at 7 days, 14 days, 28 days post-TBI. Mean concentrations were obtained from the linear mixed effect model (Table S3). Note that machine learning differentiated Vehicle-TBI and Clomi-TBI rats by all tested cytokines at 28 days post-TBI. (B) 3D dot-plots showing the differentiation of Vehicle-TBI and Clomi-TBI rats in machine learning analysis by all features [area under curve (AUC) 0.81]. (C) Summary of machine leaning analysis of Vehicle-TBI and Clomi-TBI groups. Average AUC score from 10 cross-validation. Machine learning differentiated Vehicle-TBI rats (grey) and Clomi-TBI (orange) (AUC 0.81).