Figure 3.

Altered β-cell phenotypes in diabetes. Schematic representation of β-cell described phenotypes as a response to diabetic environments. On the left side, a healthy mature β-cell is shown, in the middle box, disease stressors that induce changes in β-cell phenotype are mentioned, on the right side, summary of the three β-cell phenotypes observed in diabetes: immature/dedifferentiated, transdifferentiated and senescent, with each of the different phenotypes depicting the up- or down-regulation of key markers.