Table 2.

White blood cell count (WBC), red blood cell count (RBC), and levels of lactate, glucose, and total protein in Patients 1–11 measured at four timepoints during loading with nusinersen (timepoint 0 = before first administration, timepoint 1 = 14 days after first administration and before second, timepoint 2 = 14 days after second administration and before third, timepoint 3 = 30 days after third administration and before fourth). Levels out of reference range are highlighted in bold.

	Timepoint	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8	Patient 9	Patient 10	Patient 11
CSF WBC (/µL)	0	5	2	3	1	5	3	3	4	6	1	1
Reference range: <5/µL	1	0	0	3	3	9	5	3	3	4	2	5
	2	1	3	6	5	6	3	3	6	6	2	1
	3	1	3	3	2	4	3	1	4	3	3	0
CSF RBC (/µL)	0	<100	<100	<100	<100	<500	<500	<500	<500	<500	<500	<500
	1	<100	<100	<100	200	<500	<500	<500	<500	<500	<500	<500
	2	<100	100	<100	<500	<500	<500	<500	<500	<500	<500	700
	3	100	<500	100	<500	<500	<500	<500	<500	<500	<500	<500
CSF lactate (mM)	0	1.6	1.7	1.6	1.7	1.7	1.4	1.7	1.7	1.8	1.7	2.5
Reference range: 0.5–2.2 mM,	1	1.3	1.3	1.7	1.5	1.8	1.6	1.6	1.5	1.6	1.8	2.3
>60 years: 1.7–2.6 mM	2	1.4	1.4	1.4	1.5	1.6	1.7	1.9	1.5	1.9	1.7	2.1
	3	1.4	1.5	1.8	1.5	1.6	1.7	1.7	1.3	2.0	1.9	2.1
CSF glucose (mg/dL)	0	64	70	64	59	63	60	60	66	69	60	60
Reference range: 49–75 mg/dL	1	61	63	65	58	59	61	56	66	66	59	61
	2	58	67	60	57	63	58	60	61	70	61	55
	3	63	68	70	59	65	62	58	61	63	61	60
CSF total protein (mg/dL)	0	63	34	63	27	56	36	40	29	54	36	68
Reference range: 15–45 mg/dL	1	60	24	62	33	56	35	43	31	55	32	70
	2	66	36	63	31	50	36	40	29	55	25	80
	3	69	34	58	27	50	30	41	31	57	31	57