Table 2.
Gene therapies for ventricular tachycardia targeting L-type Ca2+ channel (LTCC).
| Author (year) | Vector | Delivery Technique | Genetic Information | Species/Model | Outcomes |
|---|---|---|---|---|---|
| Murata et al. (2004) [143] | AD | Injection into LV cavity | Mutant Ras-related G-protein Gem W296G | Guinea pig/wt | ↓ ICa-L in CMs ↓ QT in vivo |
| Cingolani et al. (2007) [144] | Lentivirus | Injection into LV cavity | Hairpin RNA for β2 | Rat/aortic-banded model of LV hypertrophy | ↓ ICa-L in CMs |
| Subramanyam et al. (2013) [145] | AD | In vitro | Split-intein-tagged α1C-fragments | Rat/wt | ↑ Ca2+ transients β-adrenergic regulation |
The origin of the genetic material used in the studies is indicated, if mentioned in the publication. Injection into the aortic root or the left ventricle (LV) cavity was performed during transient cross-clamping of the great vessels. Intramyocardial injection was performed after thoracotomy. ↓: decrease; ↑: support; AD: adenovirus; Ca2+: calcium; CMs: cardiomyocytes; ICa-L: L-type calcium current; LV: left ventricle; RNA: ribonucleic acid; VM: ventricular myocard; wt: wild-type.