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Effect of CHR on SIRT1 and the HMGB1/NF-κB signaling pathway in diabetic mice. Representative western blots and quantification of protein levels. ##P<0.01 vs. wild group; **P<0.01 vs. C57BL/KsJ-db/db group. Wild, wild-type C57BLKS/J mice; C57BL/KsJ-db/db, spontaneously diabetic mice; CHR, chrysophanol; SIRT1, silent information regulator l; HMGB1, high mobility group box 1; p-, phosphorylated; P65, NF-κB p65; IκBα, NF-κB inhibitor-α.
