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Effects of CHR on the HMGB1/NF-κB signaling pathway in diabetic mice. Immunohistochemical staining of HMGB1 and p-NF-κB (magnification, ×200). Wild, wild-type C57BLKS/J mice; C57BL/KsJ-db/db, spontaneously diabetic mice; CHR, chrysophanol; HMGB1, high mobility group box 1; p-P65-, phosphorylated NF-κB p65.
