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. 2019 Oct 24;20(21):5299. doi: 10.3390/ijms20215299

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MicroRNA (miRNA) profiling of migrated naïve placenta-derived mesenchymal stem cells (PD-MSCs) under hypoxic conditions and in bile duct ligation (BDL)-injured liver in rats. (A) Messenger RNA (mRNA)expression of hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in migrated naïve PD-MSCs determined using a Transwell insert system under 1% hypoxic conditions for 24 h, as determinedby quantitative real-time polymerase chain reaction (qRT-PCR). (B) Heat map and (C) Venn diagram of the microarray results ofmigrated naïve PD-MSCs under hypoxic conditions compared with normoxic conditions (Hyp/Nor), transplanted naïve (TTxNaïve) compared to NTx at one week (TTx/NTx 1w), and TTx Naïve compared to NTx at two weeks (TTx/NTx 2w). qRT-PCR runs were conducted in at least triplicate. Data from each group are shown as means ± SD, determined by Student’s t-test; * p < 0.05 vs. normoxia.