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. 2019 Oct 24;20(21):5299. doi: 10.3390/ijms20215299

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Improved vascular remodeling by PRL-1(+) PD-MSCs through the regulation of miRNA expression by platelet-derived growth factor receptor alpha (PDGFRA)in a BDL-injured rat model. (A) qRT-PCR of endoglin (ENG), and (B) platelet-derived growth factor receptor beta (PDGFRB) and (C) PDGFR alpha (PDGFRA)-targeted rno-miR-27a-3p expression in BDL-injured rat liver tissue after the administration of naïveand PRL-1(+) PD-MSCs at one, two, three, and fiveweeks. (D) Localizationof PDGFRA expression and (E) quantification of PDGFRA+ cells in rat liver sections from each group (Con, NTx, TTx Naïve, and TTx PRL-1(+)) at one week as determined by immunofluorescence (red, PDGFRA; blue, DAPI). Scale bars = 100 μm. All experiments wereconducted in at least triplicate. Data from each group are expressed as means ± SD, determined by Student’s t-test.* p < 0.05 vs. NTx and ^# p < 0.05 vs. TTx Naïve, wk: week.