Table I.
Top 10 GO terms ranked according to enrichment factors.
| GO ID | GO term | Description | Gene ratio (%) | P-value | Q-value | Count | Genes | Enrichment factor |
|---|---|---|---|---|---|---|---|---|
| GO:0070944 | BP | Neutrophil-mediated killing of bacterium | 2.61 | 3.15 ×10−8 | 1.46×10−5 | 4 | CTSG, TREM1, AZU1, NCF1 | 81.34 |
| GO:0051873 | BP | Killing by host of symbiont cells | 3.92 | 5.03×10−11 | 5.43×10−8 | 6 | CTSG, TREM1, NCF1, ELANE, CAMP, AZU1 | 81.34 |
| GO:0042581 | CC | Specific granule | 2.61 | 7.51×10−7 | 1.28×10−4 | 4 | ANXA3, OLFM4, CAMP, ADAM8 | 34.86 |
| GO:0001878 | BP | Response to yeast | 2.61 | 9.94×10−7 | 1.53×10−4 | 4 | NCF1, CAMP, ELANE, ADM | 32.54 |
| GO:0019865 | MF | Immunoglobulin binding | 3.27 | 1.87×10−7 | 4.65×10−5 | 5 | FCGR2B, IGJ, FCAR, FCGR1A, FCGR1B | 27.73 |
| GO:0002446 | BP | Neutrophil-mediated immunity | 3.92 | 3.90×10−8 | 1.58×10−5 | 6 | CTSG, ANXA3, ELANE, AZU1, TREM1, NCF1 | 24.4 |
| GO:0031640 | BP | Killing of cells of other organism | 3.92 | 4.75×10−8 | 1.54×10−5 | 6 | CTSG, CAMP, ELANE, AZU1, TREM1, NCF1 | 23.62 |
| GO:0002675 | BP | Positive regulation of acute inflammatory response | 2.61 | 7.17×10−6 | 7.03×10−4 | 4 | FFAR2, FFAR3, ADAM8, OSM | 20.34 |
| GO:0050829 | BP | Defense response to Gram-negative bacterium | 3.92 | 3.97×10−7 | 9.18×10−5 | 6 | AZU1, TREM1, TLR4, SLC11A1, CAMP, ADM | 16.64 |
| GO:0050832 | BP | Defense response to fungus | 3.27 | 3.13×10−6 | 3.49×10−4 | 5 | NCF1, CTSG, ELANE, CAMP, ADM | 16.05 |
‘Gene ratio’ is the ratio of the count obtained to the count expected. ‘Count’ is the number of DEGs enriched in a GO term. The ‘Genes’ column lists the gene symbols of the DEGs enriched in the corresponding GO term. BP, biological process; CC, cellular component; MF, molecular function; GO, gene ontology. Gene names are defined in Table SII.