Table 2.
MicroRNA analysis.
| Gene | miRNA | Degree | Betweenness |
|---|---|---|---|
| MCI | hsa-mir-16-5p | 15 | 29305 |
| hsa-mir-92a-3p | 11 | 13618 | |
| hsa-mir-26b-5p | 10 | 16008 | |
| hsa-mir-106b-5p | 7 | 8335 | |
| hsa-mir-93-5p | 7 | 7370 | |
| hsa-mir-20a-5p | 7 | 7297 | |
| hsa-mir-320a | 7 | 3580 | |
| hsa-let-7a-5p | 6 | 11229 | |
| hsa-mir-484 | 6 | 3618 | |
| hsa-mir-615-3p | 6 | 3342 | |
| hsa-mir-18a-3p | 5 | 8997 | |
| hsa-mir-7977 | 5 | 6593 | |
| hsa-mir-17-5p | 5 | 4484 | |
| hsa-mir-155-5p | 5 | 4269 | |
| hsa-mir-193b-3p | 5 | 3279 | |
| hsa-mir-450a-1-3p | 5 | 3266 | |
| hsa-mir-887-5p | 5 | 1840 | |
| ADD | hsa-mir-16-5p | 51 | 101307 |
| hsa-mir-26b-5p | 48 | 69947 | |
| hsa-mir-92a-3p | 33 | 53149 | |
| hsa-mir-193b-3p | 30 | 65562 | |
| hsa-mir-17-5p | 28 | 45790 | |
| hsa-mir-93-5p | 28 | 32553 | |
| hsa-mir-106b-5p | 28 | 32245 | |
| hsa-mir-20a-5p | 26 | 27726 | |
| hsa-mir-192-5p | 26 | 22623 | |
| hsa-mir-335-5p | 25 | 40587 | |
| hsa-mir-186-5p | 24 | 40049 | |
| hsa-mir-615-3p | 24 | 26450 | |
| hsa-let-7b-5p | 23 | 44950 | |
| hsa-mir-155-5p | 23 | 33976 | |
| hsa-mir-215-5p | 23 | 16736 | |
| hsa-mir-20b-5p | 21 | 16266 | |
| hsa-mir-519d-3p | 21 | 16266 | |
| hsa-let-7a-5p | 20 | 22235 |
The genes that are commonly dysregulated in the MCI arrays and in at least two of the ADD arrays were obtained using Venn diagram analysis. The genes lists were uploaded to https://www.networkanalyst.ca/NetworkAnalyst/faces/home.xhtml. The gene-microRNA interactome was created using TarBase and miRTarBase databases. The microRNAs with a degree ≥5 that may regulate the MCI genes are listed, the microRNAs with a degree ≥20 that may regulate the ADD genes are listed. In green is the microRNA that was only identified in late ADD.