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. 2019 Oct 24;20(21):5274. doi: 10.3390/ijms20215274

Figure 4.

Figure 4

CNOT1 suppression in adipocytes leads to an increase of mRNAs for immunoresponse and a decrease of those for metabolic processes. (A,B) Scatter plots of gene expression values in iWAT (A) and BAT (B) of 12-week-old control and Cnot1-AKO mice (n = 4). Black dots represent mRNAs whose expression differed more than two-fold in Cnot1-AKO mice compared to controls. (C,D) (GO) enrichment analysis of mRNAs that were upregulated (>2.0 in iWAT and >2.5 in BAT) or downregulated (<0.5) in iWAT (C) and BAT (D) of 12-week-old Cnot1-AKO mice. Bar charts of the Biological Process (BP) GO terms (at most six) ranked by the false discovery rate (FDR) (<0.05) are shown. Gene lists included in each GO term are summarized in Supplementary Tables S1 and S2. (E) Quantitative PCR analysis of the indicated mRNA levels in iWAT and BAT of 12-week-old mice (n = 4). Values in the graphs represent mean ± sem. * p < 0.05, ** p < 0.01, *** p < 0.001, unpaired t-test.