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. 2019 Nov 1;20(21):5455. doi: 10.3390/ijms20215455

Figure 8.

Figure 8

MK-8776 is cytotoxic to raft cultures of cervical cancer cell lines and increases their sensitivity to cisplatin. (A) Hematoxylin and eosin staining of tissue sections from SiHa and CaSki raft cultures, exposed to DMSO or MK-8776 at indicated concentrations from days 7 to 13 (SiHa) or 6–12 (CaSki). Cultures were harvested on last days of treatment. Cytotoxicity is evident from the degenerated tissues. (B) TUNEL assay showing apoptotic nuclei (green) in raft cultures of CaSki exposed to MK-8776, cisplatin, or both at indicated concentrations from days 9 to 12. Images were captured with 20× objective.