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. 2019 Oct 25;16(21):4112. doi: 10.3390/ijerph16214112

Figure 1.

Figure 1

Transmission electron microscopy (TEM) of PM2.5 and Mycobacterium tuberculosis (M.tb) uptake in human peripheral blood monocytes. (A,B) Endocytic vacuoles containing M.tb (white dashed arrows) showing uptake of multiple M.tb by a monocyte. (C,D) Monocyte containing air pollution PM2.5 (after 20 h exposure to 5 µg/mL PM2.5, white solid arrows). (E,F) Monocyte showing clusters of PM2.5 (white solid arrows, after 20 h exposure to 5 µg/mL PM2.5), and endocytic vacuoles containing M.tb (white dashed arrows, MOI 5) after M.tb infection for an additional 18 h. A free aggregate of PM2.5 (white circles) is visible extracellularly in panels E and F. Panels B, D, and F are zoomed images of panels A, C, and E respectively.