Table 2.
Gut microbiota in subjects grouped by age classes (i.e., tertiles) and Spearman correlation coefficients. Data were reported as median along with interquartile range (first-third quartiles). Only significant results (i.e., p-values < 0.05 from any statistical test) were reported. All p-values were adjusted controlling for the False Discovery Rate at 0.05 level within each taxonomic level.
| Spearman Correlation | |||||||
|---|---|---|---|---|---|---|---|
| Biological Classification | Microbiota | Age < 32 Years (N = 10) | Age 32–41 Years (N = 11) | Age > 41 Years (N = 10) | Test for Overall Difference (p-Value #) | Coefficient | p-Value |
| Family | Acholeplasmataceae | 0.0000 [0.0000, 0.0000] | 0.0027 [0.0006, 0.0155] | 0.0073 [0.0035, 0.0514] | 0.025 | 0.604 | 0.021 |
| Bacillaceae | 0.0000 [0.0000, 0.0000] | 0.0184 [0.0094, 0.0219] | 0.0188 [0.0071, 0.0295] | 0.025 | 0.566 | 0.029 | |
| Peptostreptococcaceae | 0.0000 [0.0000, 0.0000] | 0.0274 [0.0193, 0.0426] | 0.0364 [0.0222, 0.0432] | 0.041 | 0.536 | 0.041 | |
| Pseudomonadaceae | 0.0000 [0.0000, 0.0000] | 0.0168 [0.0090, 0.0185] | 0.0129 [0.0095, 0.0263] | 0.025 | 0.457 | 0.090 | |
| Genus | Acetivibrio | 0.0000 [0.0000, 0.0000] | 0.0142 [0.0086, 0.0238] | 0.0128 [0.0075, 0.0222] | 0.028 | 0.551 | 0.041 |
| Bacillus | 0.0000 [0.0000, 0.0000] | 0.0092 [0.0045, 0.0144] | 0.0059 [0.0032, 0.0170] | 0.028 | 0.543 | 0.041 | |
| Defluviitalea | 0.0000 [0.0000, 0.0000] | 0.0114 [0.0032, 0.0197] | 0.0225 [0.0064, 0.0257] | 0.028 | 0.649 | 0.012 | |
| Eggerthella | 0.0000 [0.0000, 0.0000] | 0.0083 [0.0019, 0.0379] | 0.0112 [0.0066, 0.0182] | 0.056 | 0.524 | 0.048 | |
| Fenollaria | 0.0000 [0.0000, 0.0000] | 0.0176 [0.0131, 0.0201] | 0.0085 [0.0060, 0.0145] | 0.039 | 0.471 | 0.089 | |
| Hydrogenoanaerobacterium | 0.0000 [0.0000, 0.0000] | 0.0193 [0.0070, 0.0257] | 0.0099 [0.0062, 0.0163] | 0.034 | 0.426 | 0.131 | |
| Lachnotalea | 0.0000 [0.0000, 0.0000] | 0.0088 [0.0063, 0.0143] | 0.0087 [0.0047, 0.0269] | 0.028 | 0.580 | 0.041 | |
| Lutispora | 0.0000 [0.0000, 0.0000] | 0.0054 [0.0030, 0.0186] | 0.0068 [0.0020, 0.0246] | 0.034 | 0.499 | 0.067 | |
| Natranaerovirga | 0.0000 [0.0000, 0.0000] | 0.0183 [0.0110, 0.0311] | 0.0200 [0.0123, 0.0215] | 0.028 | 0.528 | 0.048 | |
| Paludibacter | 0.0000 [0.0000, 0.0000] | 0.0048 [0.0024, 0.0078] | 0.0045 [0.0025, 0.0060] | 0.028 | 0.558 | 0.041 | |
| Porphyromonas | 0.0000 [0.0000, 0.0000] | 0.0251 [0.0156, 0.0273] | 0.0114 [0.0071, 0.0239] | 0.040 | 0.418 | 0.136 | |
| Pseudomonas | 0.0000 [0.0000, 0.0000] | 0.0143 [0.0079, 0.0171] | 0.0119 [0.0094, 0.0215] | 0.033 | 0.482 | 0.085 | |
| Raoultibacter | 0.0000 [0.0000, 0.0000] | 0.0043 [0.0011, 0.0139] | 0.0113 [0.0045, 0.0212] | 0.050 | 0.548 | 0.041 | |
| Species | Alistipes finegoldii | 0.1246 [0.0709, 0.6407] | 0.0038 [0.0010, 0.0653] | 0.0022 [0.0001, 0.0313] | 0.049 | −0.559 | 0.043 |
| Anaerotruncus rubiinfantis | 0.0000 [0.0000, 0.0000] | 0.0081 [0.0034, 0.0272] | 0.0076 [0.0034, 0.0120] | 0.049 | 0.466 | 0.091 | |
| Bacteroides acidifaciens | 0.0000 [0.0000, 0.0000] | 0.0193 [0.0138, 0.0321] | 0.0242 [0.0162, 0.0305] | 0.049 | 0.521 | 0.056 | |
| Bacteroides clarus | 0.0000 [0.0000, 0.0000] | 0.0035 [0.0028, 0.0559] | 0.0066 [0.0015, 0.0176] | 0.049 | 0.551 | 0.043 | |
| Bacteroides sp. ANH. 2438 | 0.0000 [0.0000, 0.0000] | 0.0005 [0.0000, 0.0012] | 0.0010 [0.0000, 0.0161] | 0.189 | 0.537 | 0.043 | |
| Bifidobacterium sp. 113 | 0.0012 [0.0001, 0.0197] | 0.0000 [0.0000, 0.0000] | 0.0000 [0.0000, 0.0000] | 0.048 | −0.580 | 0.043 | |
| Blautia luti | 0.0032 [0.0003, 0.1185] | 0.0000 [0.0000, 0.0000] | 0.0000 [0.0000, 0.0000] | 0.035 | −0.637 | 0.012 | |
| Butyricimonas sp. 180 3 | 0.0013 [0.0000, 0.0079] | 0.0000 [0.0000, 0.0000] | 0.0000 [0.0000, 0.0000] | 0.072 | −0.538 | 0.043 | |
| Butyrivibrio crossotus | 0.0017 [0.0007, 0.0027] | 0.0000 [0.0000, 0.0000] | 0.0000 [0.0000, 0.0000] | 0.048 | −0.554 | 0.043 | |
| Clostridium sp. Culture Jar 19 | 0.0000 [0.0000, 0.0000] | 0.0177 [0.0053, 0.0322] | 0.0066 [0.0036, 0.0087] | 0.048 | 0.447 | 0.097 | |
| Dialister sp. GBA27 | 0.0008 [0.0000, 0.0090] | 0.0000 [0.0000, 0.0000] | 0.0000 [0.0000, 0.0000] | 0.049 | −0.536 | 0.043 | |
| Eubacterium coprostanoligenes | 0.0000 [0.0000, 0.0000] | 0.0326 [0.0159, 0.0655] | 0.0817 [0.0316, 0.3701] | 0.058 | 0.573 | 0.043 | |
| Faecalibacterium prausnitzii | 12.7134 [10.7228, 14.3182] | 3.3569 [2.0414, 5.4147] | 5.3014 [3.4161, 6.9285] | 0.035 | −0.517 | 0.057 | |
| Fenollaria timonensis | 0.0000 [0.0000, 0.0000] | 0.0154 [0.0118, 0.0183] | 0.0074 [0.0053, 0.0129] | 0.049 | 0.477 | 0.082 | |
| Flintibacter butyricus | 0.0000 [0.0000, 0.0000] | 0.0099 [0.0011, 0.0127] | 0.0184 [0.0145, 0.0311] | 0.035 | 0.664 | 0.008 | |
| Prevotella sp. 109 | 0.0000 [0.0000, 0.0000] | 0.0025 [0.0002, 0.0068] | 0.0055 [0.0012, 0.2678] | 0.048 | 0.503 | 0.064 | |
| Robinsoniella sp. MCWD5 | 0.0000 [0.0000, 0.0000] | 0.0143 [0.0044, 0.0239] | 0.0156 [0.0081, 0.0296] | 0.049 | 0.564 | 0.043 | |
| Ruminococcus sp. DJF_VR70k1 | 0.0011 [0.0002, 0.0087] | 0.0000 [0.0000, 0.0000] | 0.0000 [0.0000, 0.0000] | 0.048 | −0.537 | 0.043 | |
| Ruminococcus sp. ID1 | 0.0000 [0.0000, 0.0000] | 0.0221 [0.0109, 0.0261] | 0.0292 [0.0172, 0.0674] | 0.048 | 0.659 | 0.008 | |
# KW: p-value from Kruskal-Wallis test.