Table 2.
TNF-α single nucleotide polymorphisms (SNPs) of all participants divided into quartiles according to serum TNF-α levels.
| Variable | Total | TNF-α (pg/mL) | |||
|---|---|---|---|---|---|
| n = 462 | <12.84 | 12.84 ≦ TNF-α <18.99 |
18.99 ≦ TNF-α <24.34 |
≧24.34 | |
| −238G > A (rs361525) | |||||
| GG | 424 (91.8) | 96 (82.8) | 109 (94.8) | 109 (94.0) | 110 (95.7) |
| AG | 34 (7.3) | 16 (13.8) | 6 (5.2) | 7 (6.0) | 5 (4.3) |
| AA | 4 (0.9) | 4 (3.4) | 0 (0) | 0 (0) | 0 (0) |
| −308G > A (rs1800629) | |||||
| GG | 365 (79.0) | 98 (84.5) | 95 (82.6) | 92 (79.3) | 80 (69.5) |
| AG | 89 (19.3) | 18 (15.5) | 20 (17.4) | 24 (20.7) | 27 (23.5) |
| AA | 8 (1.7) | 0 (0) | 0 (0) | 0 (0) | 8 (7.0) |
| −857C > T (rs1799724) | |||||
| CC | 348 (75.3) | 94 (81.0) | 88 (76.5) | 88 (75.9) | 78 (67.8) |
| CT | 103 (22.3) | 18 (15.5) | 27 (23.5) | 27 (23.3) | 31 (27.0) |
| TT | 11 (2.4) | 4 (3.5) | 0 (0) | 1 (0.8) | 6 (5.2) |
| −863C > A (rs1800630) | |||||
| CC | 415 (89.8) | 92 (79.3) | 106 (92.2) | 105 (90.5) | 112 (97.4) |
| CA | 45 (9.8) | 22 (19.0) | 9 (7.8) | 11 (9.5) | 3 (2.6) |
| AA | 2 (0.4) | 2 (1.7) | 0 (0) | 0 (0) | 0 (0) |
| −1031T > C (rs1799964) | |||||
| TT | 273 (59.1) | 72 (62.1) | 70 (60.9) | 67 (57.8) | 64 (55.7) |
| CT | 162 (35.1) | 38 (32.7) | 41 (35.6) | 42 (36.2) | 41 (35.6) |
| CC | 27 (5.8) | 6 (5.2) | 4 (3.5) | 7 (6.0) | 10 (8.7) |
Data are presented as n (%).