Table 4.
Mixed-effect model of the association of covariates and TNF-α SNPs with serum TNF-α level.
| Parameter | n | Estimate | SE | p |
|---|---|---|---|---|
| Age (year) | 0.20 | 0.05 | <0.0001 * | |
| Gender (male vs. female) | 1.84 | 1.13 | 0.104 | |
| BMI (kg/m2) | −0.39 | 0.13 | 0.002 * | |
| Smoking (yes vs. no) | 1.32 | 0.98 | 0.180 | |
| Drinking alcohol (yes vs. no) | -0.77 | 3.19 | 0.808 | |
| WBC (103/µL) | 0.75 | 0.27 | 0.006 * | |
| Pb (μg/L) | 0.22 | 0.01 | <0.0001 * | |
| Cd (μg/L) | 7.06 | 0.98 | <0.0001 * | |
| As (μg/L) | 1.13 | 0.14 | <0.0001 * | |
| Se (μg/L) | 0.03 | 0.01 | <0.0001 * | |
| Co (μg/L) | 15.56 | 2.35 | <0.0001 * | |
| Cu (μg/L) | 0.01 | 0.001 | <0.0001 * | |
| Zn (μg/L) | 0.001 | 0.0002 | <0.0001 * | |
| −238G > A(rs361525) *; −308G > A(rs1800629) * −857C > T(rs1799724)*; −863C > A(rs1800630) * −1031T > C(rs1799964) |
||||
| G-G/A-A/T-T/C-C/C-C | 3 | 44.98 | 4.79 | <0.0001 * |
| G-G/A-A/C-T/C-C/C-C | 1 | 28.78 | 8.07 | 0.0004 * |
| G-G/G-A/C-T/C-C/C-C | 2 | 17.87 | 5.81 | 0.002 * |
| G-A/G-G/C-C/C-A/C-C | 1 | −11.83 | 8.03 | 0.141 |
| G-G/G-G/C-C/C-A/C-C | 2 | −4.82 | 5.70 | 0.397 |
| G-A/G-G/C-C/C-C/C-C | 5 | −6.36 | 3.66 | 0.082 |
| G-G/G-G/C-T/C-C/C-C | 1 | 1.99 | 8.06 | 0.805 |
| G-G/G-G/C-C/C-C/C-C | 12 | 6.57 | 2.52 | 0.009 * |
| G-G/G-A/C-C/C-A/T-C | 1 | −4.32 | 8.02 | 0.590 |
| G-A/G-A/C-C/C-C/T-C | 1 | −7.81 | 8.04 | 0.332 |
| G-G/G-A/C-T/C-C/T-C | 7 | 6.71 | 3.15 | 0.033 |
| G-G/G-A/C-C/C-C/T-C | 21 | −5.53 | 1.97 | 0.005 * |
| G-A/G-G/C-T/C-A/T-C | 1 | −12.13 | 8.04 | 0.132 |
| G-A/G-G/C-C/C-A/T-C | 1 | 22.23 | 8.04 | 0.006 * |
| G-G/G-G/C-T/C-A/T-C | 1 | 1.05 | 8.03 | 0.896 |
| G-G/G-G/C-C/C-A/T-C | 4 | −6.22 | 4.06 | 0.126 |
| G-A/G-G/C-T/C-C/T-C | 4 | −4.29 | 4.60 | 0.350 |
| G-A/G-G/C-C/C-C/T-C | 10 | 9.90 | 2.75 | 0.0003 * |
| G-G/G-G/C-T/C-C/T-C | 19 | −1.82 | 2.08 | 0.380 |
| G-G/G-G/C-C/C-C/T-C | 92 | −1.57 | 1.14 | 0.167 |
| G-G/A-A/C-C/C-C/T-T | 4 | 14.90 | 4.58 | 0.001 * |
| G-G/G-A/C-T/C-A/T-T | 1 | −10.36 | 8.05 | 0.199 |
| G-G/G-A/C-C/C-A/T-T | 6 | −8.11 | 3.36 | 0.016 |
| G-G/G-A/C-T/C-C/T-T | 11 | 2.41 | 2.62 | 0.357 |
| G-G/G-A/C-C/C-C/T-T | 39 | 1.61 | 1.55 | 0.298 |
| A-A/G-G/C-C/A-A/T-T | 1 | −11.80 | 8.04 | 0.143 |
| G-A/G-G/C-C/A-A/T-T | 1 | −14.02 | 8.10 | 0.084 |
| A-A/G-G/C-C/C-A/T-T | 2 | −11.64 | 5.70 | 0.041 |
| G-A/G-G/C-C/C-A/T-T | 8 | −12.48 | 2.96 | <0.0001 * |
| G-G/G-G/C-T/C-A/T-T | 6 | −5.65 | 3.94 | 0.152 |
| G-G/G-G/C-C/C-A/T-T | 11 | −11.55 | 2.53 | <0.0001 * |
| A-A/G-G/C-C/C-C/T-T | 1 | −13.08 | 8.07 | 0.105 |
| G-A/G-G/C-C/C-C/T-T | 2 | −13.68 | 5.70 | 0.016 |
| G-G/G-G/T-T/C-C/T-T | 8 | 0.06 | 3.29 | 0.986 |
| G-G/G-G/C-T/C-C/T-T | 49 | −1.04 | 1.42 | 0.464 |
| G-G/G-G/C-C/C-C/T-T | 123 | Reference | ||
SE—Standard error; BMI—Body mass index; WBC—white blood cell; * Bonferroni’s correction p < 0.01.