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X-ray cocrystal structure of inhibitors bound to PI3Kα. (A) Sapanasertib compound 1 (PDB code: 6GVF); (B) compound 3a (PDB code: 6GVG); (C) compound 3e (PDB code: 6GVH); and (D) compound 3j (PDB code: 6GVI). Hydrogen bonds are represented by green dashed lines.
