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Table 4. HBE-TECC and CYP3A4 Induction SAR
for Aromatic Analogs 10 and 12–17.
a
HBE-TECC assay
using ABBV-2222 (0.15
μM) and GLPG1837 (0.75 μM) as the positive controls. All
values are the geometric means of at least two determinations.
b
All values are the means of at least
three determinations.