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. 2019 Oct 31;10(11):1543–1548. doi: 10.1021/acsmedchemlett.9b00377

Table 5. Pharmacokinetic Properties of 19 in Rat and Doga.

  IV dose
 oral dose
  Clb t1/2c F (%)
rat PK 0.13 3.0 53
dog PK 0.64 6.4 78
a

Parameters were determined using a 1 mg/kg dose.

b

Clearance (L/h/kg).

c

Half life (h).