Figure 1.

Schematic diagram summarizing the findings of environmental enrichment (EE)-mediated enhancement in axon regeneration of proprioceptive dorsal root ganglion (DRG) neurons.

EE exposure enhanced axon regeneration through EE-elicited neuronal activity resulting in long lasting epigenetic markings in terms of CREB binding protein (CBP)-mediated histone acetylation, which promotes the expression of regeneration associated genes (RAGs). Among the latter are those that promote the ease of Ca²⁺ release with stimuli. Ac: Acetyl group; H3: histone protein 3; H4: histone protein 4; P: phosphorylation; SCI: spinal cord injury.