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. 2019 Sep 16;15(1):128–135. doi: 10.4103/1673-5374.264466

Figure 2.

Figure 2

Effects of GLYX-13 pretreatment on cognitive function in mice 1, 3 and 7 days after isoflurane exposure.

(A) Percent freezing time in the CFC test. Percent freezing time (%) = freezing time/phase time × 100%. (B) Percent novel object exploration time in the NOR test. Percent novel object exploration time = novel object exploration time/total object exploration time × 100%. (C) Discrimination index in the NOR test. Discrimination index = (novel object exploration time-familiar object exploration time)/total object exploration time. Values are expressed as the mean ± SEM (n = 5). *P < 0.05, vs. Con group; #P < 0.05, vs. Anes group (one-way analysis of variance followed by the post-hoc least significant difference test). CFC: Contextual fear conditioning; NOR: novel object recognition. Con: Control group; Anes: isoflurane anesthesia group, in which mice were exposed to 1.5% isoflurane for 6 hours; GLYX-13: GLYX-13 injection group, in which mice were intravenously administered GLYX-13 (1 mg/kg); Anes + GLYX-13: isoflurane anesthesia + GLYX-13 injection group, in which mice were exposed to 1.5% isoflurane for 6 hours and intravenously pre-administered GLYX-13 (1 mg/kg) 2 hours earlier.