Table 4.
Expression of lncRNA BACE-AS, the fast regulator of beta-site amyloid precursor protein cleaving enzyme (BACE1) under three-week sessions of sham training or IHHT.
| Group | Healthy Control (n = 7) |
MCI + Sham (n = 6) |
MCI + IHHT (n = 8) |
Group Main Effect | Time Effect 3 Time-Points |
Group × Time Interaction |
|---|---|---|---|---|---|---|
| lncRNA BACE1-AS, relative unit | ||||||
| Pre- | 13.6 ± 10.8 | 92.5 ± 45.5 # | 85.3 ± 55.6 # | F = 11.708 | F = 1.288 | F = 0.729 |
| 1-day Post | 12.6 ± 5.9 | 75.4 ± 57.3 # | 36.8 ± 34.6 * | P = 0.001 | P = 0.288 | P = 0.075 |
| 1-month Post | 10.6 ± 7.7 | 99.3 ± 70.4 # | 45.6 ± 32.8 # |
Data are mean ± SD and analyzed with two-way ANOVA with repeated measures. Abbreviations: MCI: mild cognitive impairment; IHHT: intermittent hypoxia-hyperoxia training; Pre: Pre-IHHT baseline; 1-day Post: One day after IHHT termination; 1-month Post: One month after IHHT termination. Symbols: # p < 0.01 versus Healthy Control group; * p < 0.05 versus Pre-baseline.