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. 2019 Sep 30;18(6):4510–4516. doi: 10.3892/etm.2019.8066

Figure 5.

Figure 5.

Effect of LINC00152 knockdown on the expression of multidrug resistance-associated genes. (A) COC1 and (B) COC1/DDP cells transfected with si-1-LINC00152 or si-NC were treated with 4 or 32 µg/ml cisplatin, respectively. At 24 h post-cisplatin treatment, reverse transcription-quantitative polymerase chain reaction analysis was performed to determine the expression levels of MDR1, MRP1 and GSTπ mRNA. **P<0.01 vs. si-NC (0 µg/ml cisplatin); ###P<0.001 vs. si-1-LINC00152 (4 or 32 µg/ml cisplatin); ΔΔP<0.01 and ΔΔΔP<0.001 vs. si-NC (4 or 32 µg/ml cisplatin). si, small interfering RNA; NC, negative control; MDR1, multidrug resistance-associated gene 1; MRP1, multidrug resistance-associated protein 1; GSTπ, glutathione S-transferase π.