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. 2019 Nov 1;20(21):5463. doi: 10.3390/ijms20215463

Figure 3.

Figure 3

Effect of correctors on the expression of the CFTR N-half. Western blots of WT- (a) and F508del-M1N1 (b) transiently transfected in HEK-t cells treated with DMSO (control) or with 5 µM VX809, 5 µM VX661, 10 µM corr4a and 5 µM VX325. In the lower blots, the expression of actin, used as housekeeping protein, is shown. The molecular weight of the proteins of the molecular weight marker that was run in the SDS-PAGE is indicated on the left of each blot. The bar graphs on the right indicate the normalized expression level of WT- and F508del- M1N1. Data are expressed as mean ± standard error of the mean (SEM) of at least four independent experiments. The Dunnet test was used for data comparison. Asterisks indicate a statistical significance versus the control: * p < 0.05.