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. 2019 Oct 31;20(21):5436. doi: 10.3390/ijms20215436

Figure 1.

Figure 1

Combination of collagen-induced arthritis (CIA) model with femoral defect (FD). CIA was induced and allowed to develop for 21 days, before a cylindrical defect was performed in the femur of a half of the CIA animals to combine both animal models (CIA+FD) (A) X-ray of cylindrical defect performed on the right femur (white arrow indicates the defect site) of CIA animals at day 3 after surgery. (B) Body weight evaluation 3 days after bone defect. (C) Measurements of paw swelling in both paws (right and left) of control, CIA and CIA+FD, 3 days after bone injury. Box plots represent min-to-max distribution of n = 4 to 5 animals per group. * p < 0.05, determined by Kruskal–Wallis test and Dunn’s multiple comparisons test.