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. 2019 Nov 5;20(21):5511. doi: 10.3390/ijms20215511

Table 3.

Umbilical Cord Stem Cells.

Targeted Organ Animal Model/Human Study Cells per Dose/Administration Protocol/Location of the Injection Length of the Subjects Follow Up Effects Reported due to Stem Cells Treatment
Kidney [52] Rat 1 × 106/1 time/Left Carotid Artery 72 h
  • -

    Decrease of creatinine

  • -

    Decrease of blood urea nitrogen

  • -

    Decrease of apoptosis

  • -

    Decrease of inflammation

  • -

    Decrease of kidney Injury

  • -

    Increase of cell proliferation
Kidney [53] Mouse 5 × 105/1 time/Renal artery 7 days
  • -

    Decrease of creatinine

  • -

    Decrease of blood urea nitrogen

  • -

    Decrease of renal injury

  • -

    Decrease of reactive oxidative species

  • -

    Decrease of macrophage infiltration

  • -

    Decrease of neutrophil infiltration

  • -

    Decrease of kidney fibrosis

  • -

    Faster increase of microvascular density

  • -

    Early protective effect against apoptosis
Kidney [54] Human study for allograft 2 × 106 per kilogram before graft 1 time, vein injection/and 5 × 106 per during surgery, renal arterial injection 1 Year follow up End points (Results not reported yet NCT02490020):
Allograft rejection, kidney function, post-operatives’ complications, infection, pneumonia, bleeding.