Figure 1.
Schematic representation of the ATXN3 gene transcript (ENST00000558190.6) and reading frame, showing location of encoded protein (361 amino acid) domains below the exon map. In-frame exons are represented as rectangles, whereas those bounded by partial codons are represented with chevron sides. Exonic/intronic locations of antisense oligonucleotides designed to redirect ATXN3 pre-mRNA processing are represented as black bars above the transcript.