Table 1.
Sequences and coordinates of AOs employed in this study.
| Name | Sequence (5′–3′) |
|---|---|
| ATXN3 H9A (− 22 + 03) | UACCUGAAAACAAAACACAACACAA |
| ATXN3 H9A (+ 38 + 62) | UUCUGAAGUAAGAUUUGUACCUGAU |
| ATXN3 H9D (+ 20 − 05) | UUUACUUUUCAAAGUAGGCUUCUCG |
| ATXN3 H10A (− 17 + 08) | GCUGCUGUCUGAAACAUUCAAAAGU |
| ATXN3 H10A (+ 10 + 34) * | CUGCUGCUGCUGCUGUUGCUGCUUU |
| ATXN3 H10A (+ 35 + 59) * | GUCCUGAUAGGUCCCCCUGCUGCUG |
| ATXN3 H10D (+ 24 − 01) * | CCUAGAUCACUCCCAAGUGCUCCUG |
| ATXN3 H10A (+ 05 + 29) | GCUGCUGCUGUUGCUGCUUUUGCUG |
| ATXN3 H10A (+ 15 + 39) * | UGCUGCUGCUGCUGCUGCUGUUGCU |
| ATXN3 H10A (+ 30 + 54) | GAUAGGUCCCCCUGCUGCUGCUGCU |
| ATXN3 H10A (+ 40 + 64) | ACUCUGUCCUGAUAGGUCCCCCUGC |
| ATXN3 H10A (+ 66 + 90) | GUGGCUGGCCUUUCACAUGGAUGUG |
| ATXN3 H10A (+ 03 + 22) #/* | CUGUUGCUGCUUUUGCUGCU |
| Control AO @ | GGAUGUCCUGAGUCUAGACCCUCCG |
| Gene Tools Control | CCTCTTACCTCAGTTACAATTTATA |
* These sequences were selected for synthesis as the phosphorodiamidate morpholino oligomer chemistry (PMO). PMO oligomers are synthesised with Thymine (T) rather than Uracil (U). # Sequence from Toonen et al. (2017) [8]. @ unrelated sham control sequence. GeneTools Control; commercially available from GeneTools.