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. 2019 Nov 5;20(21):5502. doi: 10.3390/ijms20215502

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IPA^® analysis of signalling pathways of the genes differentially expressed upon lysozyme treatment. U937 cells were treated with lysozyme 15 μg/mL for 1 h and analysed immediately at the end of the treatment (1 h). Down-regulated genes by lysozyme treatment are marked in green, up-regulated genes are marked in red, orange colour indicates the prediction of an activation, blue colour the prediction of an inhibition; continuous line indicates direct relationships, dashed line indicates an indirect relationship (one or more intermediates), yellow colour indicates relationships non-consistent with the state of the down-stream molecule, grey colour indicates an unpredicted effect.