Table 2.
Differentially expressed genes in U937 cells. Whenever significant, fold change values are shown. Only genes detected as up-or down-regulated in respect of parallel control samples are shown.
| Official Symbol | Official Full Name ^ | Compartment ^ | Main Functions ^ | Fold Change at Different Analysis Time Points | ||
|---|---|---|---|---|---|---|
| 1 h | 1 h + 2 | 24 h | ||||
| Up-regulated | ||||||
| CCDC73 | Coiled-coil domain containing 73 | Intracellular (predicted) | Unknown | - | - | 7.00 |
| CKMT2 | Creatine kinase, mitochondrial 2 | Mitochondrial inner membrane | Metabolism | 20.80 | 23.25 | 14.20 |
| SCP2 | Sterol carrier protein 2 | Peroxisomal matrix | Metabolism | - | - | 2.25 |
| TMEM150C | Transmembrane protein 150C | Plasma membrane | Mechanotransduction | - | 9.20 | 24.14 |
| TTI2 | TELO2 interacting protein 2 | Cytosol | DNA damage response | 3.86 | - | - |
| WDR47 | WD repeat domain 47 | Intracellular | Development biology | - | - | 2.56 |
| Down-regulated | ||||||
| ADM | Adrenomedullin | Extracellular region | Signal transduction | −24.14 | - | - |
| CCL1 | C-C motif chemokine ligand 1 | Extracellular region | Signal transduction | −13.91 | - | - |
| CCL3 | C-C motif chemokine ligand 3 | Extracellular region | Immune system | −17.61 | - | - |
| CCL3L3 | C-C motif chemokine ligand 3 like 3 | Extracellular region | Immune system | −12.98 | - | - |
| CCL7 | C-C motif chemokine ligand 7 | Extracellular region | Immune system | −12.95 | - | - |
| DLG2 | Discs large MAGUK scaffold protein 2 | Cytosol | Neuronal system | −110.73 | −13.15 | −8.48 |
| FTH1 | Ferritin heavy chain 1 | Extracellular region; Cytosol |
Immune system; Vesicle-mediated transport; Transport of small molecules |
−2.28 | - | - |
| GDF15 | Growth differentiation factor 15 | Extracellular region | −11.97 | - | - | |
| IER3 | Immediate early response 3 | Cytosol | Signal transduction | −2.82 | - | - |
| IFI6 | Interferon alpha inducible protein 6 | Plasma membrane | Immune system | −5.40 | - | - |
| IL1B | Interleukin 1 beta | Extracellular region; Cytosol |
Immune system | −7.99 | - | - |
| IL1RN | Interleukin 1 receptor antagonist | Plasma membrane | Immune system | −6.06 | - | - |
| INHBA | Inhibin beta A subunit | Extracellular region | Metabolism of proteins; Signal transduction |
−12.72 | - | - |
| ISG15 | ISG15 ubiquitin-like modifier | Cytosol; Nucleoplasm |
Disease; Immune system; DNA repair |
−3.73 | - | - |
| MMP1 | Matrix metallopeptidase 1 | Extracellular region | Extracellular matrix organisation; Haemostasis; Metabolism of proteins; Immune system |
−4.63 | - | - |
| MMP9 | Matrix metallopeptidase 9 | Extracellular region | Development biology; Extracellular matrix organisation; Immune system; Signal transduction |
−7.52 | - | - |
| MTRNR2L2 | MT-RNR2 like 2 | Extracellular region | Programmed cell death | −2.14 | - | - |
| PLAUR | Plasminogen activator, urokinase receptor | Plasma membrane; Endoplasmic reticulum membrane; Specific granule membrane; Endoplasmic reticulum lumen |
Immune system; Metabolism of proteins |
−2.55 | - | - |
| RGS16 | Regulator of G protein signalling 16 | Plasma membrane | Signal transduction | −2.69 | - | - |
| SPP1 | Secreted phosphoprotein 1 | Extracellular region; Endoplasmic reticulum lumen |
Extracellular matrix organisation; Gene expression; Signal transduction |
−16.71 | - | - |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | Extracellular region; Platelet alpha granule lumen; Endoplasmic reticulum lumen |
Extracellular matrix organisation; Haemostasis; Immune system; Metabolism of proteins |
−2.93 | - | - |
| TJP1 | Tight junction protein 1 | Cell junctions; Plasma membrane; Cytosol; Golgi-associated vesicle membrane |
Gene expression (transcription); Programmed cell death; Vesicle-mediated transport; Signal transduction |
2.14 | - | - |
| VIM | Vimentin | Cytosol | Immune system; Muscle contraction; Programmed cell death |
−3.88 | - | - |