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. 2019 Oct 24;20(21):5269. doi: 10.3390/ijms20215269

Figure 1.

Figure 1

Celecoxib-loaded nanoemulsion (CXB-NE) ameliorates mechanical allodynia and inflammation in chronic constriction injury (CCI)-induced neuropathic male rats. (a) Mechanical stimulus evokes pain-like hypersensitivity in CCI animals. Treatment with CXB-NE provides a recovery from pain-like behavior comparable to sham and naïve control rats by day 12 (displayed as ****), but not in CCI rats given drug-free nanoemulsion (DF-NE). Data are expressed as a mean ± SD with a n = 5 per group. Significance was determined by two-way ANOVA followed by Tukey’s multiple comparison test (p < 0.0001). No statistical significance of difference of sham control compared to naïve, whereas the statistically significant difference is evident in the CCI animals compared to sham controls on days 5 through 8. (b–d) Live animal NIRF imaging on day 11 shows decreased fluorescence in CCI animals treated with CXB-NE (b), compared to those administered DF-NE (c). (d) Non-surgical naïve animals exhibit no fluorescence.