Figure 2.

Neuroinflammatory gene expression changes in mRNA of sciatic nerve isolated on day 12 post-CCI injury, four days after nanoemulsion injection. In total, 84 genes associated with neuropathic and inflammatory pain were measured from Qiagen’s RT² array (PARN-162Z). Qiagen’s RT² profiler PCR Array Data Analysis software yielded differential expression of genes given as fold regulation in (a) CCI DF-NE compared to sham control, (b) CCI CXB-NE compared to sham, and (c) comparison of the two CCI conditions. Upregulated genes (blue), downregulated genes (red), and unchanged genes (black). p value < 0.05, 2-tailed Student’s t-test. The differential expression and p values for all genes are listed in Table 1.