Table 4.

Differential expression of mRNAs typically associated with multiple cells in the periphery.

Gene Symbol	Gene Description	Fold Change Relative to Sham for CCI DF-NE	Fold Change Relative to Sham for CCI CXB-NE	Cell Expression	GenBank	Citation
Cx3cr1 1	Chemokine (C-X3-C motif) receptor 1	12.47	7.78	Macrophages, circulating monocytes, neuronal, T cells	NM_133534	[16,68]
Gch1	GTP cyclohydrolase 1	3.76	Not detected	Macrophages, neuronal, T cells, mast cells	NM_024356	[69]
Gdnf 1	Glial cell derived neurotrophic factor	1.68	4.51	Neuronal, Schwann cells	NM_019139	[70]
IL-18 1	Interleukin 18	6.57	4.27	Macrophages, circulating monocytes, neuronal, Schwann cells	NM_019165	[38,71]
IL-1β 1	Interleukin 1 beta	21.52	6.06	Macrophages, circulating monocytes, neuronal, endothelial cells	NM_031512	[72,73,74]
IL-6 1	Interleukin 6	12.5	3.63	Macrophages, circulating monocytes, Schwann cells	NM_012589	[72,75]
Maob	Monoamine oxidase B	0.16	0.09	Neuronal, Schwann cells, endothelial cells	NM_013198	[76]
Mapk3	Mitogen-activated protein kinase 3	0.62	0.40	Neuronal, Schwann cells	NM_017347	[39]
Ptger1	Prostaglandin E receptor 1	Not detected	2.29	Macrophages, neuronal	NM_013100	[77]
Ptger3	Prostaglandin E receptor 3	0.46	0.41	Macrophages, neuronal	NM_012704	[77]
Ptger4	Prostaglandin E receptor 4	2.39	2.14	Macrophages, neuronal	NM_032076	[77]
Tlr2	Toll-like receptor 2	12.22	7.12	Macrophages, circulating monocytes, Schwann cells, T cells	NM__198769	[13]
Tnf	Tumor necrosis factor	7.76	5.64	Macrophages, circulating monocytes, Schwann cells, T cells	NM_012675	[72]

¹ Denotes genes individually analyzed by qPCR.