Structures of racemic SAS-0132, JVW-1034, UKH-1114, and DKR-1677 and their binding affinities for σ1R and σ2R/Tmem97, which were determined by the Psychoactive Drug Screening Program (PDSP) at Chapel Hill, North Carolina. Average Ki values are shown for each ligand at σ1R and σ2R/Tmem97. Selected pharmacokinetic parameters (intraperitoneal administration) are given for DKR-1677.