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. Author manuscript; available in PMC: 2019 Nov 19.
Published in final edited form as: ACS Chem Neurosci. 2018 Dec 3;10(3):1595–1602. doi: 10.1021/acschemneuro.8b00543

Figure 1.

Figure 1.

Structures of racemic SAS-0132, JVW-1034, UKH-1114, and DKR-1677 and their binding affinities for σ1R and σ2R/Tmem97, which were determined by the Psychoactive Drug Screening Program (PDSP) at Chapel Hill, North Carolina. Average Ki values are shown for each ligand at σ1R and σ2R/Tmem97. Selected pharmacokinetic parameters (intraperitoneal administration) are given for DKR-1677.