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. Author manuscript; available in PMC: 2019 Nov 19.
Published in final edited form as: ACS Chem Neurosci. 2018 Dec 3;10(3):1595–1602. doi: 10.1021/acschemneuro.8b00543

Figure 2.

Figure 2.

Treatment with DKR-1677 protects mice from memory deficit after blast-mediated TBI (b-TBI). Morris water maze was used to assess hippocampal-dependent learning and memory after blast-mediated TBI. (a) Latency to find the hidden platform was used as a learning measure, and all groups showed equal ability to learn the task. (b) Platform crossing and (c) % of time spent in the target quadrant were used to measure memory in the probe test. Sham-veh (n = 16), b-TBI-veh (n = 11), b-TBI-DKR-1677 0.3 mg (n = 19), 1 mg (n = 19), 3 mg (n = 19), and 10 mg (n = 16). Values are presented as mean ± SEM. Significance was determined by one-way ANOVA with multiple comparisons. *p < 0.05, **p < 0.01, **** p < 0.0001.