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. 2019 Nov 19;38:469. doi: 10.1186/s13046-019-1456-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — SIRT4 silencing in M2-like TAMs promotes M1 macrophage apoptosis by enhancing IL-10 production in HCC peritumour tissues. a-b Investigators characterized the phenotype of apoptotic TAMs (F4/80+) and the apoptotic rate of TAMs by flow cytometry using iNOS (M1) or CD206 (M2). c FCM showed the supernatant of SIRT4 interference in M2-like TAMs on M1 TAM apoptosis. The percentage of early apoptotic cells is located in the lower right quadrant (Annexin V-FITC-positive/PI-negative), and the percentage of late apoptotic cells is located in the upper right quadrant (Annexin V-FITC-positive/PI-positive). d Supernatant of SIRT4 knocked-down M2-like TAMs with the IL-10-neutralizing antibody removed the inhibiting effects of SIRT4 interference in M2-like TAMs on M1 TAM apoptosis. *p < 0.05